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Imaging Interactions between Alzheimer's disease and cerebrovascular disease

SALSA

Computer Based Therapy

Imaging Brain Dopamine in Aging

Imaging Gene Therapy

Imaging Brain Amyloid in Vivo

Alzheimer’s Disease Neuroimaging Initiative

Mild cognitive impairment (MCI) is a term that has been used to describe cognitive decline that is intermediate between normal aging and dementia. It has received considerable attention because most people believe that therapeutic interventions will be most useful if applied prior to the onset of dementia. By identifying people with MCI, we can define a group of people who are at high risk for the subsequent development of dementia.

Some existing evidence suggests that older people who stay cognitively active have a lower risk of developing dementia. In this project a group of MCI patients will undergo computer-based training designed to produce cognitive stimulation. The goal is to see whether this produces improvement in cognitive function using a variety of outcome measures. Our laboratory will look at the effects of this cognitive therapy on brain glucose metabolism by analyzing FDG-PET studies before and after this cognitive therapy.